What is it about?

The paper describes how the second DNA polymerase in B. subtilis is connected to the replication machinery and how it participates in lagging strand replication.

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Why is it important?

The work provides a molecular understanding on the biological function of DnaE in the replication machinery in Gram-positive bacteria and shows that the lagging strand machinery deeply evolved in bacteria.

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This page is a summary of: Functional interplay of DnaE polymerase, DnaG primase and DnaC helicase within a ternary complex, and primase to polymerase hand-off during lagging strand DNA replication in Bacillus subtilis, Nucleic Acids Research, April 2013, Oxford University Press (OUP),
DOI: 10.1093/nar/gkt207.
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