What is it about?
3'-Untranslated region (UTR) shortening of mRNAs via alternative polyadenylation (APA) has important ramifications for gene expression. By using proximal APA sites and switching to shorter 3'-UTRs, proliferating cells avoid miRNA-mediated repression. Such APA and 3'-UTR shortening events may explain the basis of some of the proto-oncogene activation cases observed in cancer cells. In this study, we investigated whether 17 β-estradiol (E2), a potent proliferation signal, induces APA and 3'-UTR shortening to activate proto-oncogenes in estrogen receptor positive (ER+) breast cancers.
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Why is it important?
3'-Untranslated region (UTR) shortening of mRNAs via alternative polyadenylation (APA) has important ramifications for gene expression.
Perspectives
Estrogen (E2)-induced APA is likely to be an important but previously overlooked mechanism of E2-responsive gene expression
Dr. A. ELIF ERSON-BENSAN
Orta Dogu Teknik Universitesi
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This page is a summary of: Estrogen-induced upregulation and 3'-UTR shortening of CDC6, Nucleic Acids Research, September 2012, Oxford University Press (OUP),
DOI: 10.1093/nar/gks855.
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