What is it about?
S. pombe rad4 is an essential gene required for response to DNA damage. It has a number of roles, including in DNA replication, for which it is essential, and activation of the DNA damage checkpoint.
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Why is it important?
This is the S. pombe homologue of humanTopBP1, that has key roles in DNA replication and the G1 and S phase checkpoints
Perspectives
BRCT domains are so named because they are present in the C-terminus of the BRCA1 protein (mutations in which are responsible for a high proportion of breast and ovarian cancers). However, this paper is in fact the first identification of BRCT domains.
Dr Felicity Z Watts
University of Sussex
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This page is a summary of: Cloning and characterization of the rad4 gene of Schizosaccharomyces pombe ; a gene showing short regions of sequence similarity to the human XRCC1 gene , Nucleic Acids Research, January 1991, Oxford University Press (OUP),
DOI: 10.1093/nar/19.24.6737.
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