What is it about?
the article outlines various biochemical pathway activated in diabetes setting and how they impact the cochlear innervation and micro-blood supply. It also discusses some of the insulin signalling pathways in that sensetive tissue.
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Why is it important?
the highlight of the paper is that the diabetes-induced hearing loss could be a form of insulin resistance type of the inner ear tissue.
Perspectives
by focusing on the hypothesis that hearing impairment in diabetic patients as an insulin resistance type on the inner ear niche could open the gate for a new therapeutic targets and novel pharmacological agents.
Ahmed Gedawy
Curtin University
Read the Original
This page is a summary of: Biochemical changes to the inner ear contributing to diabetes-induced hearing loss: possible pharmacological targets for therapy, Journal of Pharmacy and Pharmacology, January 2024, Oxford University Press (OUP),
DOI: 10.1093/jpp/rgad124.
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