What is it about?
This study describes the successful use of the antibiotic cefiderocol, given continuously for 24 hours each day through an elastomeric pump, to treat a complex ear infection caused by a NDM-producing Klebsiella pneumoniae. Regular blood therapeutic drug monitoring showed that cefiderocol concentrations reached the aggressive PK/PD target, proving the method both effective and safe for outpatient care.
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Why is it important?
This is the first documented case showing that cefiderocol can be safely and effectively used in a 24-hour continuous infusion via an elastomeric pump outside of the hospital. This approach could help avoid long hospital stays and reduce healthcare costs, while maintaining high treatment effectiveness against serious drug-resistant infections. It also opens the door to more flexible outpatient antibiotic therapies for complex infections.
Perspectives
From a clinical perspective, this case represents a step forward in managing resistant infections in fragile patients. It shows how personalized therapy, supported by therapeutic drug monitoring, can offer alternatives to invasive procedures. For clinicians, it’s a practical example of how to balance efficacy, safety, and patient quality of life, especially in challenging infectious disease cases.
Professor Stefano Di Bella
Universita degli Studi di Trieste
Read the Original
This page is a summary of: Feasibility of 24 h continuous-infusion cefiderocol administered by elastomeric pump in attaining an aggressive PK/PD target in the treatment of NDM-producing Klebsiella pneumoniae otomastoiditis, JAC-Antimicrobial Resistance, April 2025, Oxford University Press (OUP),
DOI: 10.1093/jacamr/dlaf066.
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