Gene expression confirms histology marker of receptive endometria

What is it about?

Reliable histological markers have been identified of a non-receptive and a potentially receptive endometrium that are present using a less stringent method of classifying the histological section. A method that is less prone to variation in reporting , thus restoring credibility to histology reporting as an affordable, clinically applicable test in the context of reproduction.

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Why is it important?

This study has defined an expected transcriptomic characterisation of active cell proliferation in the non-receptive samples with identification of glandular mitosis the best marker of this phase. An overall marked down-regulation of proliferation in potentially receptive samples suggesting a transitional state associated with receptivity but not implantation. The receptive phase exhibited an increase in secreted glycoproteins in glands with supranuclear vacuolation.