An evaluation of propofol toxicity on mouse oocytes and preimplantation embryos

C. Tatone, A. Francione, F. Marinangeli, M. Lottan, G. Varrassi, R. Colonna
  • Human Reproduction, February 1998, Oxford University Press (OUP)
  • DOI: 10.1093/humrep/13.2.430

Anesthetics toxicity on human cells

What is it about?

One of the most important topic in anesthesia is related to the anesthetics toxicity. This research gives the exact measure of the potential damages the propofol may cause to the human oocytes.

Why is it important?

Human reproduction is more and more frequently helped by medicine. The new techniques of in vitro fertilization are also dependent on anesthesia. For this reason, it is important that the anesthetics must be as safe as possible on the vitality of the oocytes.


Professor Giustino Varrassi
Paolo Procacci Foundation

This study gives important information on the potential toxicity of propofol on the human oocytes, and open a new field of research on the importance of anesthetics, both general and local, on the survival, the apoptosis and the mechanisms of potential damage of that group of drugs.

Michael LOTTAN
Sheba Medical Center Israel

Propofol is actually widely used. Toxicity in general and on Oocytes in particular, constitutes a major concern both for patients as for medicine and presents an interesting aspect regarding the legal aspect

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The following have contributed to this page: Professor Giustino Varrassi and Michael LOTTAN