What is it about?
Triple negative breast cancers do not express hormone receptors and hence targeted therapy does not exist for this heterogeneous breast cancer subtype. Here we describe EGF (epidermal growth factor) associated generation of 3' UTR isoforms that may lead to certain oncogene activation cases
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Why is it important?
Identification of 3'UTR isoforms that are shortened or lengthened may help us identify novel cancer related genes that may have biomarker or therapy target properties.
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This page is a summary of: 3′UTR shortening and EGF signaling: implications for breast cancer, Human Molecular Genetics, September 2015, Oxford University Press (OUP),
DOI: 10.1093/hmg/ddv391.
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