What is it about?
Triple negative breast cancers do not express hormone receptors and hence targeted therapy does not exist for this heterogeneous breast cancer subtype. Here we describe EGF (epidermal growth factor) associated generation of 3' UTR isoforms that may lead to certain oncogene activation cases
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Why is it important?
Identification of 3'UTR isoforms that are shortened or lengthened may help us identify novel cancer related genes that may have biomarker or therapy target properties.
Perspectives
We need to better understand the isoform diversity in the cancer transcriptome so as to improve our knowladge on tumorigenesis.
Dr. A. ELIF ERSON-BENSAN
Orta Dogu Teknik Universitesi
Read the Original
This page is a summary of: 3′UTR shortening and EGF signaling: implications for breast cancer, Human Molecular Genetics, September 2015, Oxford University Press (OUP),
DOI: 10.1093/hmg/ddv391.
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