Susceptibility of low-density lipoprotein particles to aggregate depends on particle lipidome, is modifiable, and associates with future cardiovascular deaths

Maija Ruuth, Su Duy Nguyen, Terhi Vihervaara, Mika Hilvo, Teemu D Laajala, Pradeep Kumar Kondadi, Anton Gisterå, Hanna Lähteenmäki, Tiia Kittilä, Jenni Huusko, Matti Uusitupa, Ursula Schwab, Markku J Savolainen, Juha Sinisalo, Marja-Liisa Lokki, Markku S Nieminen, Antti Jula, Markus Perola, Seppo Ylä-Herttula, Lawrence Rudel, Anssi Öörni, Marc Baumann, Amos Baruch, Reijo Laaksonen, Daniel F J Ketelhuth, Tero Aittokallio, Matti Jauhiainen, Reijo Käkelä, Jan Borén, Kevin Jon Williams, Petri T Kovanen, Katariina Öörni
  • European Heart Journal, July 2018, Oxford University Press (OUP)
  • DOI: 10.1093/eurheartj/ehy319

The quality of LDL is a new risk factor in cardiovascular diseases

What is it about?

LDL particles accumulate in the arterial wall, where they become modified and aggregate. We developed a novel assay to measure the susceptibility of plasma LDL particles to aggregate. Importantly, we found that among patients with an established coronary artery disease the presence of aggregation-prone LDL was predictive of future cardiovascular deaths. We further found that differences in the composition of LDL determine their susceptibility for aggregation. The quality of LDL could be improved by a healthy diet or by cholesterol-lowerin medication (PCSK9 inhibition).

Why is it important?

There is a need for new approaches when diagnosing patients with unrecognized risk for cardiovascular disease events. We think that the the measurement of LDL aggregation susceptibility could be used as a novel biomarker of cardiovascular risk that may add predictive power to the conventional risk estimation. The biomarker may facilitate identification of patients who would benefit most from aggressive LDL-lowering therapies.

Perspectives

Dr Katariina Öörni
Wihuri Research Institute

A long journey - but so worth it. I'm really proud of the whole group for getting this huge piece of work published.

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http://dx.doi.org/10.1093/eurheartj/ehy319

The following have contributed to this page: Dr Katariina Öörni