What is it about?
This paper describes an essential role of NOTCH-TNF signaling in the valve endothelium for normal arterial valve development and homeostasis. It reports disruptive NOTCH-TNF signaling in mice leading to congenital bicuspid aortic valves and aortic valve stenosis similar to the conditions seen in human patients.
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Why is it important?
This is the first work discovering a tissue specific NOTCH function in the valve endothelium for arterial valve development and disease. The finding suggests abnormal NOTCH signaling in the valve endothelium as a critical part of pathogenesis of congenital bicuspid aortic valves and aortic valve stenosis.
Perspectives
This work opens a new avenue for developing non-invasive medicine for aortic valve stenosis, which has no effective therapies except for surgical valve replacement.
Dr Bin Zhou
Albert Einstein College of Medicine
Read the Original
This page is a summary of: Notch-Tnf signalling is required for development and homeostasis of arterial valves, European Heart Journal, October 2015, European Society of Cardiology,
DOI: 10.1093/eurheartj/ehv520.
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