What is it about?
A recent study with 3.5 million people showed normal weight individuals are at increased risk of cardiovascular death if they are metabolically unhealthy. Then, what would be the effect on heart if normal weight individuals get fit? Our study showed the weight loss is associated with better heart function even in the normal weight population.
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Why is it important?
Obesity has been claimed to result in death. However, the effect of weight reduction was only proved in the extremely obese population. In this study, we showed that weight loss impacts the heart function even in normal weight population. This study is essential in preventive medicine as it provides evidence that efforts to reduce weight improve cardiac function.
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This page is a summary of: OUP accepted manuscript, European Heart Journal - Cardiovascular Imaging, January 2017, Oxford University Press (OUP),
DOI: 10.1093/ehjci/jex219.
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Relations between BMI and the LV indices
Relations between BMI and the LV indices (A: left atrial volume index; B: E/Eʹ ratio; C: Eʹ velocity). The black line represents the population regression line based on BMI. Each grey line indicates a person’s fitted line connected by the corresponding fitted values over the observed range of BMI. These fitted lines are straight lines under our model assumption. (A) left atrial volume index; (B) E/Eʹ ratio; (C) Eʹ velocity. The slope of each fitted line was 0.80 in (A) (95% CI 0.38 to 1.23, P < 0.001), 0.11 in (B) (95% CI − 0.015 to 0.23, P = 0.086) and −0.11 in (C) (95% CI: −0.18 to − 0.031, P = 0.006). The BMI decrease was significantly associated with improved indices of LV diastolic function after adjusting for age, gender, and other covariates. A one-unit decrease in BMI between consecutive visits corresponded to an average decrease in LA volume index of 0.80 mL/m2 (A), a decrease in E/Eʹ ratio of 0.11 (B), and an increase in Eʹ velocity of 0.11 cm/s (C).
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