What is it about?
Women and men, female and male animals and cells are biologically different. We need to study sex differences in cardiovascular and brain function, heart and liver disease and others. We must use animal models, cell cultures, engineered human tissues and stem cells.
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Why is it important?
Knowledge on sex differences in animal models, on different metabolic pathways and physiology is needed for interpretation of human diseases. At a time of personalized medicine and precision medicine, we have to understand differences between women and men for understanding differences in the response to therapy .
Perspectives
Knowing differences between women and men will help to target therapies to both groups, as it is the goal of personalized medicine or precision medicine.
Professor Vera Regitz-Zagrosek
Charite Universitatsmedizin Berlin
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This page is a summary of: Sex in basic research: concepts in the cardiovascular field, Cardiovascular Research, May 2017, Oxford University Press (OUP),
DOI: 10.1093/cvr/cvx066.
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