Metabolomics and biomarkers in Chronic Kidney Disease

What is it about?

Chronic kidney disease (CKD) is a growing burden on people and on healthcare for which the diagnostics are neither disease-specific nor indicative of progression. Biomarkers are sought to enable clinicians to offer more appropriate patient-centred treatments, which could come to fruition by using a metabolomics approach. This mini-review highlights the current literature of metabolomics and CKD, and suggests additional factors that need to be considered in this quest for a biomarker, namely the diet and the gut microbiome, for more meaningful advances to be made

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Why is it important?

The article provides a comprehensive overview of the current literature on the use of metabolomics technologies used to identify potential biomarkers of CKD and CKD progression from clinical studies. The emphasis on diet, nutritional status and microbiome in particular, is very relevant and are important considerations if metabolomics are to be used as tools in the clinical setting.