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Why is it important?
This study shows a likely mechanism underlying individual differences in attention bias to threat in healthy adults. This relationship is a likely pathway through which a genetic factor — BDNF val66met SNP — confers a risk for pathological anxiety that is related to abnormally increased attention bias to threat.
Perspectives
I am extremely pleased to be a co-first author of this study. Thanks to Josh's hard work and excellent experimentation, we obtained a very clean dataset ranging from an attention bias behavior task, SNP (single nucleotide polymorphism) data, and diffusion MRI. Rigorous methodologies were used to test relationships among genetic, behavioral, and neural data: e.g., path analyses and bootstrapping model comparison. Overall, clean and multiple/complimentary units of analysis and statistical significance of results made our manuscript writing and review process easy as it can be.
Dr JIOOK CHA
Columbia University
Read the Original
This page is a summary of: Influence of the BDNF Genotype on Amygdalo-Prefrontal White Matter Microstructure is Linked to Nonconscious Attention Bias to Threat, Cerebral Cortex, April 2013, Oxford University Press (OUP),
DOI: 10.1093/cercor/bht089.
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