What is it about?
Tumor promoters are believed to have a threshold. However, this study demonstrates that the acceleration of liver tumor formation in mice by an insecticide is linearly related to the dose level with no indication of a threshold.
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Why is it important?
The dose-response relationship of tumor promotion points to an irreversible mechanism of action.
Perspectives
Tumor promotion is relevant for humans with cancer predisposition
Dr Henk A. Tennekes
Experimental Toxicology Services (ETS) Nederland BV
Read the Original
This page is a summary of: Quantitative aspects of enhanced liver tumour formation in CF-1 mice by dieldrin, Carcinogenesis, January 1985, Oxford University Press (OUP),
DOI: 10.1093/carcin/6.10.1457.
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