What is it about?
Identifying transcription factor binding sites within DNA sequences is difficult because they can be simple and common sequences that may be spatially distributed across the DNA sequence. This work investigate the use of phylogenetic information by aligning sequences across multiple species to look for conserved sequences that can be given greater weighting when searching for these binding sites
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Why is it important?
Transcription factor binding sites are critical to understanding how genes are regulated. This work looks to improve the way we identify them within the genome.
Read the Original
This page is a summary of: Assessing phylogenetic motif models for predicting transcription factor binding sites, Bioinformatics, May 2009, Oxford University Press (OUP),
DOI: 10.1093/bioinformatics/btp201.
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