What is it about?

Gstp is most notable for its roles in detoxification and deoxidation as well as cell development and apoptosis. Our study found that Gstp knockdown in the developing cortex results in neuronal morphology defects.

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Why is it important?

Our findings show the importance of Gstp in neurite formation, especially the early step of neurite formation called neurite initiation. This is the first evidence about the importance of Gstp in cortical development.


There are little studies about the involvement of Gstp in neurological diseases. I hope our findings in this article will attract clinicians and basic scientists to the Gstp implication in neurodevelopmental disorders.

Kazuhito Toyooka
Drexel University

Read the Original

This page is a summary of: Glutathione S-transferase Pi (Gstp) proteins regulate neuritogenesis in the developing cerebral cortex, Human Molecular Genetics, January 2021, Oxford University Press (OUP),
DOI: 10.1093/hmg/ddab003.
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