What is it about?
Miller-Dieker syndrome (MDS) is caused by the microdeletion of the chromosome 17p13.3, called MDS critical region. It is well known that Lis1, Crk and 14-3-3epsilon in 17p13.3 are responsible genes for MDS. However, the MDS critical chromosome region contains 26 gens, including PEDF (Serpinf1). Therefore, we analyzed and found the importance of PEDF and its receptor Rpsa in cortical development. PEDF plays a key role in neurite formation and spine formation during cortical development.
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Why is it important?
Our findings show PEDF-Rpsa (receptor for PEDF)-Itga6 regulates neurite formation and spine formation. Serpinf1gene, coding for PEDF protein, is localized on chromosome 17p13.3, where often deleted or duplicated in Miller-Dieker syndrome (MDS) and the 17p13.3 microduplication syndrome. Defects in neurite formation affects later steps of neuronal development, such as neural connectivity and neural activity. MDS patients suffer from severe seizure. Therefore, our finding gives the first evidence that the defects in the PEDF signaling pathway is involved in MDS.
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This page is a summary of: Rpsa Signaling Regulates Cortical Neuronal Morphogenesis via Its Ligand, PEDF, and Plasma Membrane Interaction Partner, Itga6, Cerebral Cortex, August 2021, Oxford University Press (OUP), DOI: 10.1093/cercor/bhab242.
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