What is it about?

Papillomavirus L1 has proven effective to generate protective neutralizing antibody in vivo. This study further demonstrated that L1 can stimulate T cell mediated immune responses as well. A preclinical rabbit model system was used for this study.

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Why is it important?

This is first in vivo evidence to show L1 induced cell-mediated immune response is protective. The N-terminal of L1 contribute this effect.

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This page is a summary of: Protective Cell-Mediated Immunity by DNA Vaccination against Papillomavirus L1 Capsid Protein in the Cottontail Rabbit Papillomavirus Model, Viral Immunology, September 2006, Mary Ann Liebert Inc,
DOI: 10.1089/vim.2006.19.492.
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