Cancer Risk Associated with Nuclear Atypia in Thyroid Nodules with Indeterminate Cytology

What is it about?

There are many different cytological scenarios that can fall into the indeterminate categories of thyroid cytology. In this study we found that cytologically indeterminate thyroid nodules exhibiting nuclear atypia in the cytological specimen were consistently associated with a cancer risk around 2.5 times higher than nodules without nuclear atypia.

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Why is it important?

The presence/absence of nuclear atypia may impact the results' interpretation of molecular marker tests; and has significant implications for management recommendations. Incorporating the presence or absence of nuclear atypia in reporting systems of thyroid cytology is likely to improve (i) the cytological–histological correlation, (ii) communication between pathologists and clinicians, and (iii) sharing information between institutions for research purposes.

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