Early Initiation of Endochondral Ossification of Mouse Femur Cultured in Hydrogel with Different Mechanical Stiffness

Gulsan Ara Sathi, Kodai Kenmizaki, Satoshi Yamaguchi, Hitoshi Nagatsuka, Yasuhiro Yoshida, Aira Matsugaki, Takuya Ishimoto, Satoshi Imazato, Takayoshi Nakano, Takuya Matsumoto
  • Tissue Engineering Part C Methods, June 2015, Mary Ann Liebert Inc
  • DOI: 10.1089/ten.tec.2014.0475

Early initiation of endochondral ossification of mouse femur cultured in hydrogel

What is it about?

We hypothesized that hydrogel with different mechanical stiffness can provide a biomimetic mechanical environment that can modulate bone tissue growth and mineralization.

Why is it important?

Since this system enhances and shortens the mineralization procedure compared with the conventional two-dimensional or three-dimensional cell culture system, this hydrogel system would be one of the unique models for better understanding the mineralized tissue development.

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The following have contributed to this page: Dr Satoshi Yamaguchi