What is it about?
We have shown that CO, a gas transmitter, plays a key role as a mediator, along with NO, in fine turning the Ca2+ signaling between the two Ca2+ second messengers NAADP and cADPR.
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Why is it important?
Our findings show that CO plays a role in bridging the gap between the Ca2+ signaling messengers during insulin secretion in pancreatic b-cells. Thus, HO-2-activating agents or CO donors have the potential to be used as a therapeutic agent for diabetic patients. .
Perspectives
I hope you find this article shows an example of important role of gas transmitters in cellular physiological function.
Professor Uh-Hyun Kim
Chonbuk National University Medical School
Read the Original
This page is a summary of: Critical Roles of Carbon Monoxide and Nitric Oxide in Ca2+ Signaling for Insulin Secretion in Pancreatic Islets, Antioxidants & Redox Signaling, April 2018, Mary Ann Liebert Inc,
DOI: 10.1089/ars.2017.7380.
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