What is it about?
By nature, most of the excipients might be inert. It is essential to know that the excipients are not only for bulking up the formulation but also place a vital part in the bioavailability enhancement of BCS class II and IV drug molecules through a pragmatic way of experimentations. In this review, consolidated the wide range of excipients portfolio along with the applications used for the bioavailability improvement of poorly water-soluble compounds so that the user can able to identify and select the suitable excipients as per the nature of the drug molecule.
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Why is it important?
Here in this review, we attempted to provide the wide-ranging of excipients which were pragmatically proved a substantial part in bioavailability enrichment of poorly water-soluble drug compounds.
Perspectives
Nowadays most of the drug substances are coming into the innovation pipeline with poor water solubility. Here, the influence of excipients will play a significant role to improve the dissolution of poorly aqueous soluble compounds.
Mr Manoj Kumar Vadlamudi
VIT University
Read the Original
This page is a summary of: Significance of excipients to enhance the bioavailability of poorly water-soluble drugs in oral solid dosage forms: A Review, IOP Conference Series Materials Science and Engineering, November 2017, Institute of Physics Publishing,
DOI: 10.1088/1757-899x/263/2/022023.
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