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We move the selectivity filter Asp112 of hHV1 up and down the S1 transmembrane segment. Three positions allow current, 109, 112 (WT) and 116; all face the pore in our model (Kulleperuma et al, 2013). Asp109 (D112A/V109D) permits anion current, but does not enforce H+ selectivity. Asp116 (D112V/V116D) produces excellent proton currents. MD indicates that proton selectivity requires that Asp (or Glu) interact with Arg to neutralize its charge.

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This page is a summary of: Peregrination of the selectivity filter delineates the pore of the human voltage-gated proton channel hH V 1 , The Journal of General Physiology, November 2013, Rockefeller University Press,
DOI: 10.1085/jgp.201311045.
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