Deuterium Isotope Effects on Permeation and Gating of Proton Channels in Rat Alveolar Epithelium

What is it about?

Voltage-gated proton currents are studied in heavy water. Deuterium can permeate, but does so only half as well as protons, suggesting a more complex permeation pathway than a simple water wire, as found in most other ion channels.

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