Two different treatments produce two distinct Th2-type responses
What is it about?
The immune system has a number of different and observably distinct responses to foreign invaders. One of these responses is called Th2, which is typically brought into play when the body becomes infected by parasites and bacteria. In an attempt to better understand this Th2-type response of the immune system, we applied two different Th2-inducing treatments to mouse ears (a parasite, and a chemical paste), then looked at how genes were influenced by these treatments. While these two treatments appear to produce the same response on the outside (i.e. Th2), we looked under the hood and saw almost completely different cellular machinery to deal with the different treatments.
Why is it important?
The Th2 response is known to be important in many types of allergy. Any treatments for allergy need to be targeted to deal with the correct underlying biological system. Our research suggests that a single treatment will not work for Th2 allergies, and there needs to be a classification of the type of allergy before treatment.
The following have contributed to this page: Dr David A Eccles