What is it about?

The immune system exquisitely self-regulates to bring powerful responses to infection to bear without damaging the body. A major part of this command & control system is a protein called ubiquitin, which attaches to proteins of the immune system to alter their movement and function in cells. However, viruses exploit this same process to prevent immune activation while also rerouting other key cellular functions. Here, I review our current understanding of how ubiquitin is used and abused in immune control. 人間の免疫系は体の自己免疫ダメージを防ぐし、感染に対して強い応答を活性するために自動的に制御される。「ユビキチン」というタンパク質はこのシステムに重要な部分の一つです。ユビキチンは細胞のタンパク質を付けることにより、ユビキチンは免疫関連タンパク質の移動および機能を変更します。しかし、同じプロセスを操ることにより、ウイルスは免疫系に加えて細胞のいろいろな機能を管制します。本稿では、免疫系を制御するために体およびウイルスはユビキチンを使う方法を説明したい。

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Why is it important?

If we clarify how ubiquitin regulates immunity and how diverse viruses use ubiquitin to their advantage, I believe we may create entirely new kinds of antiviral treatments and immune therapies. そんなメカニズムを解明できたら、新しい種類の抗ウイルス療法や免疫療法を発明することができると思います。


It was a privilege to be invited to write this article. Controlling the function of proteins in space and time is essential for both cell survival and viral infection. I hope this overview of the 'wiring diagram' of the immune system and its control by ubiquitin will stimulate further research in this important area.

Dr. Steven Heaton
RIKEN Center for Integrative Medical Sciences

Read the Original

This page is a summary of: Ubiquitin in the activation and attenuation of innate antiviral immunity, The Journal of Experimental Medicine, December 2015, Rockefeller University Press,
DOI: 10.1084/jem.20151531.
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