What is it about?
Antiviral activity was detected in porcine leukocytes obtained from animals killed in a slaughterhouse. The activity appeared in the supernatant immediately after the addition of Sendai virus, an intended interferon (IFN) inducer. Electroinduction appears to be responsible for the production of antiviral molecules in both porcine and human leukocytes. The macromolecule conferring the antiviral activity is sensitive to heat and pH 2.0 treatment. The preformed or electro-induced antiviral activity originating from porcine leukocytes was not neutralized by either anti-PoIFN-α or anti-PoIFN-γ. The substance involved differs from all known antiviral proteins in that it is not secreted spontaneously into the extracellular space. Its release requires intact and virulent Sendai virus as a trigger signal. Differences in antigenic properties and characteristics indicate that this is a new antiviral substance.
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Why is it important?
Our research clearly shows the appearance of new IFN-like molecules with strong biological activity
Perspectives
We hope, that these molecules could in near future be used for cancer treatment.
Dr. Bratko Filipič
Univerza v Ljubljani
Read the Original
This page is a summary of: INDUCTION OF ANTIVIRAL RESPONSE BY ELECTRIC PULSES, Electro- and Magnetobiology, January 2000, Taylor & Francis,
DOI: 10.1081/jbc-100102119.
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