What is it about?
The mathematical error of Rigler’s et al. intuitive approaches to equations of local concentration fluctuations in the behavior of few molecules is that they did not sum up over an infinite number of periods before making any averaging. That is the reason why their approaches do not work.
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Why is it important?
It must be made crystal clear that the underlying physics and molecular biochemistry can be modified easily but things hardly get worse when there is any trouble with the mathematics which rules the physical and biological formulations. The paper of Földes-Papp et al. (2001) "Detection and identification of single molecules in immunology and immunohematology: single (solution)-phase single-molecule FCS" in Hematology 6: 423-428 equates to it.
Perspectives
Földes-Papp et al. (2001) "Detection and identification of single molecules in immunology and immunohematology: single (solution)-phase single-molecule FCS" in Hematology 6: 423-428.
PRESERVE FROM BEING FORGOTTEN: Professor Zeno Földes-Papp [Biochemist, Gerontologist (Biochemiker, Geriater)]: Laying the Foundation of Single-Molecule Biophysics & Biochemistry Based On the Stochastic Nature of Diffusion: The Individual Molecule, from the Mathematical Core to the Physical Theory. -- I hope that my humble scientific work will be well received by the communities of single-molecule imaging and spectroscopy and by all users of these technologies as well as biotechnologies in the various and different disciplines:
Head of Geriatric Medicine (Medical Director of the Geriatric Service: Sektionsleitung Geriatrie) at Asklepios Klinikum Lindau (Bodensee), Bavaria, Germany
Read the Original
This page is a summary of: Detection and Identification of Single Molecules in Immunology and Immunohematology: Single (solution)-phase Single-molecule FCS, Hematology, January 2001, Taylor & Francis,
DOI: 10.1080/10245332.2001.11746597.
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