MiMe-NoCoDI model of thyroid homeostasis

What is it about?

This paper presents the outline of a cybernetic theory of pituitary-thyroid feedback control. The mathematical model is based on physiological and biochemical properties of included organs and compartments. Key elements of this bottom-up model are Michealis-Menten kinetics, noncompetitive divisive inhibition and ASIA elements. Fractal analysis of computer simulations with SimThyr demonstrate the biological relevance of TSH ultrahort feedback.

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Why is it important?

This nonlinear theory of thyroid homeostasis explains the behaviour of the feedback loop from basic biochemical and molecular properties. Therefore it may be better founded than other models of hypothalamic-pituitary-thyroid axis. This model predicted the existence of TSH ultrahort feedback (Brokken-Wiersinga-Prummel loop).