Assessment of synergistic effect of combining hyperthermia with irradiation and calcium carbonate nanoparticles on proliferation of human breast adenocarcinoma cell line (MCF-7 cells)

  • Nasrollah Jabbari, Leila Zarei, Hadi Esmaeili Govarchin Galeh, Bahman Mansori Motlagh
  • Artificial Cells Nanomedicine and Biotechnology, April 2018, Taylor & Francis
  • DOI: 10.1080/21691401.2018.1457537

synergistic effect of combining hyperthermia with irradiation and CC nanoparticles on MCF-7 cells

What is it about?

In radiotherapy, combination of nanoparticles with ionizing radiation, as a radio-sensitizer, improves the contrast between cancerous and normal tissues by increasing local radiation dose. In addition, hyperthermia has been indicated to be effective in cancer treatments when combining with radiation therapy and/or chemotherapy.

Why is it important?

Our findings revealed that calcium carbonate nanoparticles (CC NPs) in combination with irradiation and hyperthermia could significantly reduce the cell viability and enhance the apoptosis of the MCF-7 breast cancer cells, the same as doxorubicin anti-cancer drug.


Dr Nasrollah Jabbari
Urmia University of Medical Sciences

Our results indicated that the synergistic effect of combining hyperthermia, irradiation and calcium carbonate nanoparticles (CC NPs) could be comparable with doxorubicin (P3), as an anti-cancer drug. In summary, the present work reveals that using CC NPs combination with hyperthermia and radiation can have promising applications in the treatment of MCF-7 cancer cells.

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The following have contributed to this page: Dr Nasrollah Jabbari