OMV-based vaccine formulations against Shiga toxin producing Escherichia coli strains are both protective in mice and immunogenic in calves

Matias Fingermann, Lucía Avila, Maria Belén De Marco, Luciana Vázquez, Darío Nicolás Di Biase, Andrea Verónica Müller, Mirta Lescano, José Christian Dokmetjian, Sonsire Fernández Castillo, José Luis Pérez Quiñoy
  • Human Vaccines & Immunotherapeutics, June 2018, Taylor & Francis
  • DOI: 10.1080/21645515.2018.1490381

OMV-based vaccines aimed at fighting against HUS

What is it about?

This is a preliminary study on OMV potential use as vaccines for lowering shedding from the naural reservoir (domestic cattle) of the zoonotic Shiga toxin producing Escherichia coli (STEC), one of the most prominent agents responsible for Hemolityc Uremic Syndrome (HUS). OMV's potential for preventing deleterious effects of STEC toxins is also evaluated.

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