What is it about?
With Adenocarcinomas, solid tumors such as colon cancer, host- tumor interactions are of major importance in controlling the progression and severity of the tumor. We show that the immune response can sculpt the genomic heterogeneity of the tumor. These interactions provides opportunities for both therapy and prevention of cancer.
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Perspectives
Current treatments of adenocarcinomas are surgery, with its anatomic limitations which debulk the tumor and often leaves residual occult disease, chemotherapy and Irradiation which are marginally effective with corrolary damage. What is needed is a treatment which is personal, more precise and prevents tumor progression. The personalized approach described provides a pathway to better treatment for the majority of cancer patients and offers a pathway to a broadly prophylactic vaccine.
Michael Hanna
Read the Original
This page is a summary of: A key to the backdoor into the castle: The clinical ramifications of immunoediting driven by antigenic competition, Human Vaccines & Immunotherapeutics, March 2017, Taylor & Francis,
DOI: 10.1080/21645515.2017.1301337.
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