Fabrication of biocomposites composed of natural rubber latex and bone tissue derived from MC3T3-E1 mouse preosteoblastic cells

  • Mitsuru Furuya, Naoki Shimono, Masami Okamoto
  • Nanocomposites, April 2017, Taylor & Francis
  • DOI: 10.1080/20550324.2017.1352111

Bionanocomposites composed of natural rubber and bone tissue derived from MC3T3-E1 cells

What is it about?

To broaden our knowledge of application in tissue engineering of natural rubber latex (NRL), we have focused on the surface modification of NRL nanoparticles through the biomineralization of hydroxyapatite (HA) using simulated body fluid in order to create a better cytocompatibility with controlled cell adhesion and mineralization properties in osteogenic culture to determine the effect on bone outcomes.

Why is it important?

In order for NRL nanoparticles to be employed in regenerative medicine, they need to have designed biological interaction with cells as well as favorable mechanical properties. Cells can delicately sense and respond to external nano-scale features in intricate living systems. With this in mind, an in-depth understanding of cell differentiation may bring a new perspective to regenerative medicine including new bone regeneration and cartilage therapy. To the best of our knowledge, no attention has been paid to differentiation activity of NRL nanoparticles.


Dr. Masami Okamoto
Toyota Technological Institute

The results showed promise of the NRL nanoparticles for application in bone tissue engineering. We believe this article may be of particular interest to not only the readers of this composite journal but also the cross-disciplinary researchers of molecular cell biology.

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The following have contributed to this page: Dr. Masami Okamoto