Characterization of SCL33 splicing patterns during diverse virus infections in Brachypodium distachyon

Kranthi K Mandadi, Jesse D Pyle, Karen-Beth G Scholthof
  • Plant Signaling & Behavior, July 2015, Taylor & Francis
  • DOI: 10.1080/15592324.2015.1042641

What is it about?

In this study, we analyzed the splicing patterns of a Brachypodium splicing factor, Bd-SCL33, during infection with seven viruses.

Why is it important?

We found dynamic and conserved changes in Bd-SCL33 splice variants during virus infections. Many of the splice variants contain pre-mature termination codons and encode truncated proteins, that could inhibit the activity of full-length Bd-SCL33 protein in a dominant negative manner.

Perspectives

Kranthi Kiran Mandadi (Author)
Texas A&M University

Modulation of Bd-SCL33 activity could represent a means to control genome-wide changes in splicing landscapes during biotic stress.

The following have contributed to this page: Kranthi Kiran Mandadi