DNMT1 modulates interneuron morphology by regulating Pak6 expression through crosstalk with histone modifications

Judit Symmank, Cathrin Bayer, Christiane Schmidt, Anne Hahn, Daniel Pensold, Geraldine Zimmer-Bensch
  • Epigenetics, August 2018, Taylor & Francis
  • DOI: 10.1080/15592294.2018.1475980

Interactions of DNMT1 with histone modifications in interneuron development

What is it about?

It describes how a DNA methylating enzyme can modulate neuronal morphology by regulating gene expression through interactions with histone modifying complexes

Why is it important?

The knowledge about the role of epigenetic mechanisms in orchestrating inhibitory interneuron development is still very fragmented. However, epigenetic gene control appears extremely important for setting up discrete transcription programs in particular interneuron subsets displaying subtype-specific modes of development, which is addressed here.

The following have contributed to this page: Geraldine Zimmer-Bensch