What is it about?
We have analyzed the structural and physicochemical properties of protein-protein (PP), protein-RNA (PR) and RNA-RNA (RR) interfaces in small and large subunits of ribosomes, as well as in between the two subunits. Additionally, we have also developed Random Forest (RF) classifier to catalog the r-proteins.
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Why is it important?
Interactions between macromolecules play a crucial role in ribosome assembly that follows a highly coordinated process involving RNA folding and binding of ribosomal proteins (r-proteins). we have used Random Forest (RF) classifier to catalog the r-proteins in the ribosomal assemblies that support the hypothesis that large PR interfaces form first and promote the assembly to a higher order.
Perspectives
This article might help the researchers in understanding on how the macromolecular interaction networks stabilize the ribosomal assemblies.
smita pilla
Indian Institute of Technology Kharagpur
Read the Original
This page is a summary of: Dissecting macromolecular recognition sites in ribosome: implication to its self-assembly, RNA Biology, June 2019, Taylor & Francis,
DOI: 10.1080/15476286.2019.1629767.
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