What is it about?

G protein coupled receptors are the largest class of cell surface proteins and are the target of more than 30% of drugs on the market. This editorial provides a general scientific overview of our earlier "Cell" paper, along with work of others, on what underlying mechanisms might explain why some drugs have bigger effects than other drugs.

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Why is it important?

This work is important because many pharmaceutical companies now seek to utilise the fact that different drugs, acting at the same receptor, can generate differing strengths of response. Understanding the underlying biochemistry and biology will be important in leveraging drug differences.

Read the Original

This page is a summary of: What determines the magnitude of cellular response for activation of G protein-coupled receptors?, Cell Cycle, January 2017, Taylor & Francis, DOI: 10.1080/15384101.2016.1271634.
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