What is it about?

This study have led to the identification of an endophytic filamentous fungus Bipolaris sp. with high ophiobolin A production (235 mg/L) in liquid culture after 21 days. Our findings further indicate that ophiobolin A-producing fungi live in short-cycle plants, and a method of finding the fungus is described.

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Why is it important?

Ophiobolin A, a metabolite of fungi, is known to induce cell death and have anticancer activity. Therefore, obtaining ophiobolin A has become an important aspect in studying activity with medicinal properties that are affected by it.


We can conveniently isolate endo- phytic fungi that produce ophiobolin A in high quantities using our investigation method. We hope that this report will promote the supply of ophiobolin A and con- tribute to the further advances in the research of bioactive anticancer mechanisms.

Shoji Maehara
Fukuyama Daigaku

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This page is a summary of: High ophiobolin A production in endophytic fungus Bipolaris sp. associated with Datura metel, Natural Product Research, April 2019, Taylor & Francis, DOI: 10.1080/14786419.2019.1597352.
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