What is it about?

Chemotherapy-induced neutropenia is a common adverse event in cancer patients undergoing chemotherapy. We have shown that Chemotherapy-induced neutropenia in colorectal cancer patients, particularly in metastatic colorectal cancer patients, had a potential benefit for survival.

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Why is it important?

Our findings show that Chemotherapy-induced neutropenia, which caused by a particular dosage of a chemotherapeutic agent, may also be a surrogate marker to assess whether patients receive an effective or adequate active dose. Actually, the recommended dosage of chemotherapy was obtained from a small number of patients, do not take into account the interindividual variability of drug metabolism, so it may not suitable for everybody.

Perspectives

Chemotherapy-induced neutropenia could be utilized as a surrogate marker to determine the adequate antitumor dose of chemotherapeutic agents for colorectal cancer patients.

Xiangzhou Tan
XiangYa Hospital of Central South University

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This page is a summary of: Chemotherapy-induced neutropenia and the prognosis of colorectal cancer: a meta-analysis of cohort studies, Expert Review of Anticancer Therapy, September 2017, Taylor & Francis,
DOI: 10.1080/14737140.2017.1380521.
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