Microarray analysis of circulating microRNAs in familial Mediterranean fever

  • Taizo Wada, Tomoko Toma, Yusuke Matsuda, Akihiro Yachie, Saori Itami, Y-h Taguchi, Yoshiki Murakami
  • Modern Rheumatology, February 2017, Taylor & Francis
  • DOI: 10.1080/14397595.2017.1285845

What is it about?

Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by mutations in MEFV. Mutations in exon 10 are associated with typical FMF phenotypes, whereas the pathogenic role of variants in exons 2 and 3 remains uncertain. Recent evidence suggests that circulating microRNAs (miRNAs) are potentially useful biomarkers in several diseases. Therefore, their expression was assessed in FMF.

Why is it important?

Using the expression patterns of 26 miRNAs, we classified FMF (groups A, B, and C) and PFAPA with 78.1% accuracy. In FMF patients, groups A and B, A and C, and B and C were distinguished with 93.8, 87.5, and 100% accuracy using 24, 30, and 25 miRNA expression patterns, respectively.

Perspectives

Professor Y-h. Taguchi
Chuo Daigaku

As a bioinformatics researcher, it is a part of a series of studies where PCA based unsupervised FE, which is described here. https://www.researchgate.net/project/Principal-Component-Analysis-based-unsupervised-Feature-extraction

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http://dx.doi.org/10.1080/14397595.2017.1285845

The following have contributed to this page: Professor Y-h. Taguchi