Single strand breaks in DNA and breast cancer
What is it about?
Single strand breaks in SSBs measured in fine needle aspirates of the breast by the nick translation procedure are associated with, but not redundant with, measures of breast cancer risk and with deficiencies of both DNA damage repair processes and antioxidant mechanisms. Breast tissue 4-hydroxyœstradiol may serve an antioxidant function and may protect against the occurrence of SSGs.
Why is it important?
Quantitative measurement of single strand breaks in DNA are shown in this paper to be positively related to an important measure of breast cancer risk: percent breast density. Another measure of breast cancer risk, the cumulative methylation index was also positively associated with SSB. Expression of XRCC1, NRF-1, SOD2, and 4-hydroxyœstradiol were significantly negatively associated with SSB. A strong difference in expression of these factors in pre- vs post-menopause was observed.
The following have contributed to this page: Robert Chatterton