The relationship of single-strand breaks in DNA to breast cancer risk and to tissue concentrations of oestrogens

  • Mathavi Sahadevan, Oukseub Lee, Miguel Muzzio, Belinda Phan, Lisa Jacobs, Nagi Khouri, Jun Wang, Hong Hu, Vered Stearns, Robert T. Chatterton
  • Biomarkers, February 2017, Taylor & Francis
  • DOI: 10.1080/1354750x.2017.1293736

Single strand breaks in DNA and breast cancer

What is it about?

Single strand breaks in SSBs measured in fine needle aspirates of the breast by the nick translation procedure are associated with, but not redundant with, measures of breast cancer risk and with deficiencies of both DNA damage repair processes and antioxidant mechanisms. Breast tissue 4-hydroxyœstradiol may serve an antioxidant function and may protect against the occurrence of SSGs.

Why is it important?

Quantitative measurement of single strand breaks in DNA are shown in this paper to be positively related to an important measure of breast cancer risk: percent breast density. Another measure of breast cancer risk, the cumulative methylation index was also positively associated with SSB. Expression of XRCC1, NRF-1, SOD2, and 4-hydroxyœstradiol were significantly negatively associated with SSB. A strong difference in expression of these factors in pre- vs post-menopause was observed.

Perspectives

Robert Chatterton
Northwestern University

Measurement of single strand breaks in DNA from fine needle aspirates of the breast provides an early measure of breast cancer risk that is related to a number of different types of risk measures without being a replicate of any of these other measures.

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http://dx.doi.org/10.1080/1354750x.2017.1293736

The following have contributed to this page: Robert Chatterton