Combined Administration of l-Carnitine and Ascorbic Acid Ameliorates Cisplatin-Induced Nephrotoxicity in Rats

Quadri Kunle Alabi, Rufus Ojo Akomolafe, Olaoluwa Sesan Olukiran, Aliyat Olajumoke Nafiu, Modinat Adebukola Adefisayo, Olurotimi Isaac Owotomo, Joseph Gbenga Omole, Kehinde Peace Olamilosoye
  • Journal of the American College of Nutrition, February 2018, Taylor & Francis
  • DOI: 10.1080/07315724.2017.1409139

Combine effect of l-carnitine and vitamin C mitigate renal injury induce by cisplatin

What is it about?

We have shown that combination of l-carnitine and vitamin C can inhibit oxidative stress effect of cisplatin on renal function

Why is it important?

Our findings show that both l-carnitine and vitamin C can boost animals immune system and as well prevented renal damage effect of anticancer drug cisplatin. Thus these can be use in human for the treatment of acute renal injury


Quadri Alabi (Author)
Obafemi Awolowo University

This article lead to understanding of antioxidant and antiinflammatory beneficial of l-carnitine and vitamin C as one of it cofactor.

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The following have contributed to this page: Mr Olaoluwa OS Olukiran and Quadri Alabi