What is it about?
Testing various synthetic materials coated on one side with pig endothelial cells to possibly serve as a substitute for donor material for the Descemet's membrane endothelial keratolasty (DMEK) procedure
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Why is it important?
Due to a lack of good quality human donor corneas, we are currently limited to one donor eye to make one corneal transplant. If synthetic materials could bu used as a substitute, then one could use one donor's endothelium organ/tissue-cultured into many cells subsequently transplanted onto multiple artificial surfaces: one donor to make many donors.
Perspectives
This is an early step in the process. Different synthetic materials should be tested to find those biocompatible with human corneal endothelium as well as being biomechanically similar to human Descemet's Membrane while being biocompatible with the host cornea so that unfolded it will remain attached to the posterior cornea.
Perry Binder
Gavin Herbert eye Institute, University of California, Irvine, CA
Read the Original
This page is a summary of: Evaluation of the Suitability of Biocompatible Carriers as Artificial Transplants Using Cultured Porcine Corneal Endothelial Cells, Current Eye Research, October 2018, Taylor & Francis,
DOI: 10.1080/02713683.2018.1536215.
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