What is it about?
Cancer remains a second leading cause of deaths and major public health problem. It occurs due to extensive DNA damage caused by ultraviolet radiations, ionizing radiations, environmental agents, therapeutic agents, etc. Among all cancers, the most frequently diagnosed cancers are lung (12.7%), breast (10.9%), colorectal (9.7%), and gastric cancer (7.81%). Natural compounds are most favorable against cancer on the count of their anti-cancerous ability, easy to avail and efficient. Among natural compounds, polyphenols (flavonoids, catechin, hesperetin, flavones, quercetin, phenolic acids, ellagic acid, lignans, stilbenes, etc.) represent a large and diverse group used in the prevention and treatment of cancer. Natural flavonoids are derived from different plant sources and from various medicinal plants including Petroselinum crispum, Apium graveolens, Flemingia vestita, Phyllanthus emblica, etc. Natural flavonoids possess antioxidant, anti-inflammation, as well as anti-cancerous activities through multiple pathways, they induce apoptosis in breast, colorectal, and prostate cancers, lower the nucleoside diphosphate kinase-B activity in lung, bladder and colon cancers, inhibit cell-proliferation and cell cycle arrest by suppressing the NF-kB pathway in various cancers, etc.
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Why is it important?
The burden of cancer is increasing day by day, many therapies have been considered for its treatment but due to adverse effects, these therapies are lethal to health. In the context of this, in our manuscript, we used organic derived compounds to treat cancer effectively without any side effect to normal cells.
Perspectives
Cancer is a mind-boggling process which includes in the multiplication of cells, it remains a moment driving reason for death comprehensively. Lung, breast, colorectal, and stomach cancers are the most prominent cancer among all. Pakistan has the most elevated breast cancer proportion among the Asian nations. Natural compounds are most supported for the treatment of cancer because of their security, proficiency, straightforwardness to accessibility, and hostile to malignant capacity. Phytochemicals are shown a significant role against various malignancies, but among all, natural polyphenol compounds (flavonoids) represent a broad and assorted group in the anticipation and treatment of cancer. Natural polyphenols have their anticancer exercises through various pathways, including cancer prevention agent enzymatic movement, cell cycle arrest (S/G2, G1, S, and G2 stages), by regulating the Nrf2 and NF-κB cells, inhibit the cell-proliferation, prompt apoptosis, MAPK flagging pathway, and so on.
Mr. Abu Hazafa
Universita degli Studi di Salerno
Read the Original
This page is a summary of: The Role of Polyphenol (Flavonoids) Compounds in the Treatment of Cancer Cells, Nutrition and Cancer, July 2019, Taylor & Francis,
DOI: 10.1080/01635581.2019.1637006.
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