What is it about?

The relevance of the work is the incorporation of a phosphoramidate group into the thieno[2,3-b]pyridine system, constituting an interesting synthetic strategy used in the discovery of new drugs.

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Why is it important?

The present manuscript describes the synthesis and characterization by IR, 1H-, 13C-, 31P-NMR spectroscopy and HRMS of new thieno[2,3-b]pyridine phosphoramidates compounds were synthesized and characterized. The crystal structures of two compounds were solved by X-ray diffraction and showed a network of intermolecular interactions involving phosphoramidate groups.

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This page is a summary of: Synthesis, Crystal Structures, and in Silico Toxicity Prediction of Thienopyridine Phosphoramidates, Synthetic Communications, December 2013, Taylor & Francis, DOI: 10.1080/00397911.2013.786092.
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