What is it about?
Specific insulin receptors were identified on nerve endings in the circum-ventricular organs (CVOs). The capillaries perfusing CVOs are fenestrated allowing access for circulating peptides viz. insulin, leptin etc.
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Why is it important?
Describes a key mechanism by which circulating insulin and other peptides communicate with the CNS to alter behavior and function.
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This page is a summary of: Insulin interaction with the central nervous system: nature and possible significance, Proceedings of The Nutrition Society, February 1987, Cambridge University Press,
DOI: 10.1079/pns19870013.
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