What is it about?
Describes the role of Rab35 in TCR transport for the Immune Synapse formation
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Why is it important?
Two models explain the accumulation of the TCR at the Immune Synapse, one is lateral movement of proteins at the membrane and the other involves intracellular transport in vesicles, we showed that Rab35 is important for the second mechanism
Perspectives
When we publish this paper there was no Rab described as important for the Immune Synapse formation we described a functional pair (Rab-Rab-GAP) working on this important topic
Dr. Genaro Patino-Lopez
Children's Hospital of Mexico
Read the Original
This page is a summary of: Rab35 and Its GAP EPI64C in T Cells Regulate Receptor Recycling and Immunological Synapse Formation, Journal of Biological Chemistry, April 2008, American Society for Biochemistry & Molecular Biology (ASBMB),
DOI: 10.1074/jbc.m800056200.
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