Dominant Role of Thyrotropin-releasing Hormone in the Hypothalamic-Pituitary-Thyroid Axis

What is it about?

In this paper, the authors pointed out TRH as the main regulator of Hypothalamic-pituitary-axis.

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Why is it important?

For many years, negative feedback by T3 was considered the main regulator of the thyroid axis. In this paper, using double knock-out mouse models, we have showed the fundamental role of TRH.